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| 货号 | RC0261 |
| 说明书 | |
| CAS号 | 15307-79-6 |
| 分子式 | C14H10Cl2NO2•Na |
| 分子量 | 318.13 |
| 产品描述 | |
| 描述 | 本品为前列腺素合成抑制剂，具有抗炎、镇痛作用。局部应用。其有效成份可穿透皮肤达到炎症区域，缓解急、慢性炎症反应，使炎性肿痛减轻、疼痛缓解。标准的NSAID以及环氧合酶(COX)抑制剂；用于CYP2C9的选择性基质。 |
| 纯度 | >98%，BR级 |
| 储存/保存方法 | 常温，避光防潮密闭干燥，有效期3年。 |
| 产品用途 | 科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。 |
| 基本信息 | |
| 别名 | 双氯灭痛; 2-[(2,6-二氯苯基)氨基]-苯乙酸钠;2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | 溶于水、乙醇、DMSO等 |
| 生物活性 | |
| 靶点 | NMDA receptor,Potassium channel |
| In vitro(体外研究) |  Flupirtine pre-incubated for 2 hours prevents cell death in rat cortical neurons induced by NMDA and gp120 of HIV-1. Flupirtine is capable of protecting primary neurons against glutamate-induced cytotoxicity by reducing calcium ion concentrations at 1-10 mM. Flupirtine pretreated for 2 hours preventsβ-amyloid-induced apoptosis in primary neuronal cells at concentrations of 1 or 5μg/mL. Flupirtine at concentration of 10 μM markedly decreases nonreceptor-mediated necrotic cell death in PC 12 cultures treated with 10 mM L-glutamate, meanwhile, Flupirtine exerts anti-oxidative effects in PC 12 cultures. Flupirtine-maleate at concentrations of 1 μM and 10 μM decreases TRAIL-mediated death of human living brain tissue culture. Flupirtine activates inwardly rectifying potassium ion channels and thus stabilizes the resting membrane potential at a therapeutically relevant concentration. |
| In vivo(体内研究) | Pre-treatment with Flupirtine exerts a protective effect on hippocampal and striatal neuronal damage and on deficits in spatial learning in rats with cerebral ischemia. Flupirtine administered centrally inhibits the nociceptive responses induced by chemical, thermal, mechanical and electrical stimuli in animal studies. Flupirtine exerts muscle relaxant effects in rat. |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 | |
